GMP, CLEANROOM & COMPUTER ROOM CLEANING

In GMP cleanroom environments, eliminating spore-forming microorganisms is critical to maintaining compliance and product safety. Sporicide cleaning plays a vital role in decontamination, targeting resilient microorganisms that standard cleaning methods may not fully address.

What Is Sporicide Cleaning?

A sporicide is a powerful disinfectant specifically formulated to destroy spore-forming microorganisms, which are among the most difficult to eliminate. Spores can survive in harsh environments and remain viable for extended periods, making them a significant risk in controlled environments.

When Is Sporicide Cleaning Required?

• Initial Validation Cleaning:
  • Sporicide cleaning is often performed as part of the initial validation process to establish a baseline for cleanliness and contamination control.
• Periodic Application:
  • Subsequent sporicide cleanings are conducted at regular intervals, determined by the validation outcomes and documented in the facility’s Standard Operating Procedures (SOPs).
  • The frequency may vary based on contamination risks, product type, and regulatory requirements.

Why Sporicide Cleaning Is Important

• Eliminates Resistant Contaminants:
  • Spore-forming microorganisms, such as certain bacteria and fungi, are highly resistant to standard disinfectants. Sporicide cleaning ensures their effective removal.
• Maintains GMP Compliance:
  • FDA regulations require facilities to demonstrate that all cleaning protocols, including sporicide applications, effectively control microbial risks.
• Protects Product Integrity:
  • Thorough decontamination reduces the likelihood of contamination, safeguarding product quality and consumer safety.

ACM’s Expertise in Sporicide Cleaning

• Tailored Solutions:
  • ACM develops sporicide cleaning protocols specific to your facility’s needs, ensuring compliance with validation outcomes and SOPs.
• Certified Technicians:
  • Our team is trained in handling sporicides safely and effectively, minimizing risks to personnel and equipment.
• Documentation and Validation:
  • ACM provides detailed records of sporicide cleaning activities, ensuring audit readiness and transparency.

Partner with ACM for Effective Sporicide Cleaning

ACM’s GMP sporicide cleaning services are designed to:

• Effectively eliminate spore-forming microorganisms.
• Support compliance with FDA and GMP regulations.
• Maintain a contamination-free environment to protect your products and processes.

Contact ACM today to ensure your cleanroom meets the highest standards of safety and compliance.

At ACM, we understand that Standard Operating Procedures (SOPs) are the backbone of regulatory compliance and operational consistency. That’s why we specialize in creating, documenting, and delivering GMP-compliant SOPs tailored to meet your specific requirements.

What ACM Provides:

1. Custom SOP Development:
   • ACM collaborates with your team to develop SOPs that address your facility’s unique cleaning and operational needs.
   • Every SOP is crafted to ensure alignment with the most current Good Manufacturing Practices (GMPs) and international regulatory agency requirements.
2. Continuous Improvement:
   • SOP documentation is regularly reviewed and updated to reflect:
     • Changes in regulatory standards.
     • Advancements in cleaning technology and methodology.
     • Feedback from audits, inspections, and operational outcomes.
   • This ensures both ACM’s SOPs and customer-specific SOPs stay relevant and effective.
3. Expertly Written Documentation:
   • SOPs are developed by area experts with deep knowledge of regulatory compliance, ensuring clarity, precision, and adherence to industry standards.

Training and Certification

ACM ensures that all facilities and technicians are thoroughly trained and certified on the SOPs and GMP requirements for documentation:

• Comprehensive Training:
  • Technicians receive hands-on instruction to ensure proper implementation of the cleaning protocols outlined in the SOPs.
  • Training also covers GMP documentation practices, emphasizing accuracy, consistency, and traceability.
• Effortless Compliance:
  • ACM’s training programs equip your team with the knowledge and skills to maintain compliance effortlessly, ensuring readiness for audits and inspections.

Why GMP SOP Documentation Matters

• Regulatory Compliance:
  • Properly documented SOPs demonstrate adherence to FDA, ISO, and other international regulatory standards.
• Operational Consistency:
  • Clear, precise SOPs provide a roadmap for consistent and effective cleaning practices, reducing variability and risks.
• Audit Readiness:
  • Comprehensive documentation ensures that your facility is always prepared for inspections and audits.

Partner with ACM for SOP Excellence

When you choose ACM, you gain a partner dedicated to delivering tailored SOPs that:

• Ensure compliance with the latest regulations.
• Support consistent and effective cleaning practices.
• Provide effortless compliance through expert-written documentation and training.

Let ACM help you establish and maintain GMP-compliant SOPs that protect your cleanroom, products, and reputation. Contact us today to learn more about our GMP cleaning SOP documentation services.

ACM’s Supercleans provide an intensive, top-to-bottom cleaning solution designed to meet the most rigorous cleanroom and controlled environment standards. This method ensures comprehensive removal of contaminants, maximizing cleanliness and minimizing risks.

The Superclean Process

1. Top-to-Bottom Cleaning:

   • Cleaning begins at the ceiling or highest point and progresses down the walls to the floor, ensuring that dislodged particles are captured systematically.

2. Clean-to-Less-Clean Workflow:

   • The process starts in the cleanest area, typically farthest from the exit door, and moves toward the least clean area, such as the entry/exit point.
   • This flow minimizes cross-contamination and ensures optimal cleanliness throughout the room.

3. Frequency Tailored to Your Needs:

   • The number and frequency of Supercleans are customized based on your project’s requirements, facility usage, and contamination risks.

Components of a Superclean

Supercleans can include a range of specialized cleaning services, based on your facility’s unique needs:

• Top-Down Cleaning:

  • Comprehensive cleaning of all surfaces, including ceilings, walls, and floors.

• Air Handler Unit (AHU) Cleaning:

  • Ensures clean airflow by removing contaminants from AHU components, including filters, ducts, and vents.

• Raised Floor Cleaning:

  • Targets contaminants trapped beneath raised flooring systems, preventing particle migration into the cleanroom environment.

• Plenum Area Cleaning:

  • Cleans overhead plenums and sub-plenum spaces, critical for maintaining proper airflow and reducing contamination risks.

• High-Bay Cleaning:

  • Focuses on elevated areas like rafters, beams, and lighting grids that often accumulate dust and debris.

• Computer Room and Data Center Cleaning:

  • Designed to prevent dust buildup that can interfere with sensitive electronics, ensuring optimal equipment performance and reducing downtime risks.

Why Choose ACM for Supercleans?

• Comprehensive Expertise:

  • ACM’s certified technicians are trained to address all aspects of a Superclean, using specialized tools and techniques to achieve unmatched cleanliness.

• Tailored Solutions:

  • Each Superclean is customized to fit the specific needs of your facility, whether it’s a pharmaceutical cleanroom, data center, or manufacturing space.

• Regulatory Compliance:

  • Our processes meet or exceed ISO, GMP, and other regulatory standards, ensuring your facility is always audit-ready.

Experience the ACM Superclean Difference

With ACM’s Supercleans, you can trust that every surface in your facility will be thoroughly cleaned and decontaminated, enhancing your operations and ensuring compliance. Contact us today to schedule a Superclean tailored to your needs and discover why ACM is the trusted choice for controlled environment cleaning.

The Clean-Build process is a structured approach to ensuring cleanrooms are designed, built, and maintained in a state of cleanliness throughout construction and certification. This methodology focuses on starting clean, building clean, and staying clean to minimize contamination risks and ensure regulatory compliance.

ACM is proud to offer industry-leading Clean-Build construction cleaning methods, following the five levels of clean construction protocols outlined in ISO 14644-4.

The Clean-Build Protocol Levels

ACM follows a five-level protocol system, ensuring meticulous cleaning at every stage of construction:

1. Level 1 to Level 2: Rough Clean

   • Removal of large debris, construction dust, and contaminants generated during initial construction phases.
   • Ensures a cleaner environment to prepare for finer cleaning processes.

2. Level 2 to Level 3: Top-Down Before Blow-Down

   • Comprehensive top-down cleaning of all surfaces to remove settled particles before the blow-down phase.

3. Level 3: Pre-Level 4 Cleaning

   • Top-Down Cleaning: Focuses on elevated surfaces, walls, and floors.
   • Filter Grid Cleaning: Ensures HEPA or ULPA filter grids are free from contaminants.
   • Raised Floor Cleaning: Removes particles from subfloor spaces and under raised flooring systems to maintain airflow integrity.

4. Level 4 to Level 5: Final Clean

   • A final, comprehensive cleaning of the entire cleanroom to ensure it is free of contaminants.
   • Includes all surfaces, equipment, and airflow systems, preparing the cleanroom for certification.

5. Continuous Cleaning:

   • During construction, ACM provides daily cleaning services to maintain cleanliness and prevent contamination buildup.

Additional Clean-Build Services

When constructing a cleanroom, ACM offers a full suite of services to support the Clean-Build process:

• Protocol Communication:

  • Clear guidance on cleaning and construction protocols for each level.

• Protocol Training:

  • Training for construction teams on temporary gowning, material entry procedures, and contamination prevention strategies.

• Temporary Gowning and Material Entry Rooms:

  • Setup and monitoring of dedicated areas to maintain cleanliness during material handling and personnel movement.

• Cleanroom Supplies and Garmenting:

  • Provision of cleanroom-approved supplies and garments tailored to each protocol level.

• Process Monitoring:

  • Continuous oversight of the Clean-Build process to ensure compliance with ISO 14644-4 and other applicable standards.

Why ISO 14644-4 Matters

ISO 14644-4 defines the standards for Clean-Build protocols and specifications, ensuring:

• Controlled construction methodologies to minimize contamination risks.
• A consistent framework for designing and building cleanrooms.
• Seamless transitions between construction phases, culminating in a fully certified cleanroom.

Partner with ACM for Clean-Build Excellence

ACM’s Clean-Build cleaning and construction services ensure your cleanroom meets the highest standards of cleanliness and compliance from the start of construction to final certification. Our expertise and commitment to excellence make us the trusted choice for cleanroom construction projects.

Contact us today to learn more about how ACM can support your Clean-Build process and provide tailored solutions for your cleanroom needs.

Validation cleaning is a critical step in establishing and maintaining a GMP-compliant cleanroom environment. This process ensures that all cleaning procedures deliver predictable, consistent results as documented in the Standard Operating Procedures (SOPs). These results are used to define alert and action limits for ongoing compliance.

What Is Validation Cleaning?

Validation cleaning confirms the effectiveness of your GMP cleaning protocols through a structured process, ensuring:

• Predictable Results: Cleaning methods are tested and proven to meet the required cleanliness standards consistently.
• Compliance Readiness: Results are validated to meet ISO, GMP, FDA, and other regulatory standards.
• Establishment of Limits: Environmental monitoring results are statistically analyzed to set alert and action limits for ongoing monitoring.

Key Aspects of Validation Cleaning

1. SOP Validation and Maintenance:

   • Cleaning procedures documented in SOPs are rigorously tested during validation.
   • Any future changes to SOPs after successful validation require a re-validation process to ensure continued compliance and effectiveness.

2. Environmental Monitoring Integration:

   • Validation results are confirmed through statistical analysis of environmental monitoring data.
   • Trends in particulate and microbial contamination levels are evaluated to verify cleaning effectiveness.

3. Adjustments During Validation:

   • Validation cleaning may require changes to:
     • Disinfectants: Testing different solutions to determine the most effective options.
     • Sporicides: Introducing or alternating sporicides to target specific microbial risks.
     • Cleaning Materials and Wipes: Evaluating compatibility and efficiency for various surfaces and contaminants.

Why Is Validation Cleaning Important?

• Ensures Regulatory Compliance:

  • Establishes confidence that your cleaning procedures meet the strict requirements of GMP and other regulatory frameworks.

• Improves Operational Consistency:

  • Validated cleaning protocols provide a reliable foundation for maintaining a cleanroom environment, reducing variability and contamination risks.

• Supports Audit Readiness:

  • Proper validation ensures your facility is always prepared for inspections, with documented evidence of cleaning effectiveness.

ACM’s Expertise in Validation Cleaning

ACM provides comprehensive post-construction GMP validation cleaning services to help your cleanroom achieve and maintain compliance:

• Custom Validation Protocols:

  • Tailored cleaning procedures and validation methods based on your facility’s unique requirements.

• Certified Technicians:

  • Trained professionals experienced in validation cleaning processes and regulatory standards.

• Detailed Documentation:

  • Thorough records of validation activities, including SOP updates, environmental monitoring results, and statistical analyses.

Achieve Predictable Results with ACM

ACM’s post-construction GMP validation cleaning services ensure your cleanroom is fully validated and compliant from day one. By partnering with ACM, you gain:

• Proven cleaning methods tailored to your facility.
• Statistical analysis of results to establish clear action and alert limits.
• Expert guidance on maintaining compliance through ongoing SOP updates and re-validation processes.

Contact ACM today to learn how we can support your cleanroom validation process and provide the peace of mind that comes with guaranteed compliance.

ACM extends its expertise in sophisticated cleanroom cleaning systems to provide top-tier office and industrial janitorial services. Designed for our valued cleanroom customers, these services deliver the same attention to detail, professionalism, and compliance-driven methodologies in non-GMP environments.

Our janitorial services prioritize green cleaning solutions, using sustainable, environmentally safe products that protect both the planet and the people in your facility.

Janitorial Services Offered by ACM

ACM offers a wide range of services tailored to meet the unique needs of office and industrial environments:

• Office Cleaning: Comprehensive cleaning for workspaces, including desks, floors, and high-touch areas.
• Kitchen Sanitization: Deep cleaning and sanitization of kitchens and breakrooms to maintain hygienic conditions.
• Blind Cleaning: Careful cleaning of window blinds to remove dust and allergens.
• Carpet Care: Professional carpet cleaning to extend lifespan and improve indoor air quality.
• Construction Cleanup: Post-construction cleaning services to remove dust, debris, and contaminants.
• Medical Waste Disposal: Safe handling and disposal of medical waste in compliance with regulatory standards.
• Emergency Services: Rapid response cleaning for unforeseen situations such as spills, leaks, or accidents.
• General Maintenance: Routine cleaning and upkeep to maintain a safe and functional workspace.
• Hard Surface Floor Care: Specialized cleaning and maintenance for hard surfaces, including polishing and sealing.
• Inventory Control: Managing cleaning supplies and ensuring availability for uninterrupted operations.
• Light Industrial Cleaning: Cleaning and maintenance services for light industrial facilities.
• Pressure Washing: Effective cleaning for exterior surfaces, removing grime, stains, and pollutants.
• Restroom Sanitation: Thorough cleaning and disinfecting of restrooms for a hygienic experience.
• Special Event Services: Pre- and post-event cleaning to ensure your space is spotless.
• Supply Management: Monitoring and replenishing cleaning supplies as needed.
• Upholstery Cleaning: Professional cleaning of upholstered furniture to maintain appearance and hygiene.
• Window Cleaning: Streak-free cleaning of windows for a polished, professional look.

Why Choose ACM for Janitorial Services?

• Green Cleaning Practices:

  • ACM uses eco-friendly, sustainable cleaning products to promote a safe, healthy environment.

• Expertise Across Industries:

  • With decades of cleanroom cleaning experience, ACM brings a meticulous and compliance-driven approach to all cleaning tasks, even in non-GMP settings.

• Comprehensive Solutions:

  • From daily office cleaning to specialized industrial maintenance, ACM tailors services to fit your needs.

• Trusted Partnership:

  • Our non-GMP cleaning services provide the same level of reliability and satisfaction that cleanroom customers have come to expect from ACM.

Elevate Your Janitorial Services with ACM

Whether you need routine office cleaning, specialized industrial services, or event support, ACM is here to help. Our commitment to excellence and sustainability ensures your facility remains clean, safe, and productive.

Contact ACM today to discuss your janitorial needs and discover how our tailored services can support your operations.

For more information on our Janitorial cleaning service visit our page HERE

Maintaining the cleanliness of your computer rooms and data centers is essential to ensuring the integrity and performance of your equipment. Dust, dirt, and other contaminants can compromise sensitive electronics, leading to system failures, downtime, and costly repairs. ACM guarantees to leave your computer rooms 3 to 10 times cleaner, creating a safer and more reliable environment for your critical operations.

Comprehensive Cleaning Services

ACM’s certified technicians follow a meticulous cleaning process to target all areas of your computer room or data center:

1. Under the Raised Floors:

   • The plenum space beneath raised floors accumulates particles due to gravity and airflow dynamics.
   • ACM removes these contaminants to maintain clean air circulation and prevent particles from being deposited in equipment.

2. Floor Surfaces:

   • Cleaning includes both the tops and undersides of floors to eliminate surface contamination.

3. Room and Equipment Interiors/Exteriors:

   • Dust and particles are removed from equipment surfaces, vents, and interiors using HEPA-filtered vacuums and compatible cleaning solutions.

Specialized Cleaning Techniques

• Bottom-Up Cleaning:

  • Unlike cleanrooms, computer rooms are cleaned starting from the bottom up (raised floors) and progressing to the room’s highest points.
  • Cleaning is performed from the area farthest from the exit, moving toward the entry point to minimize cross-contamination.

• HEPA Vacuum Systems:

  • ACM uses Nilfisk HEPA-filtered vacuums to capture particles as small as 0.5 microns, ensuring even the smallest contaminants are effectively removed.

• Surface Surfactants:

  • For particles not captured by vacuums, ACM applies specialized surfactants tailored to the surface and equipment type.

• Compatible Cleaning Supplies:

  • Wipes, mops, and cleaning solutions are carefully selected to ensure compatibility with sensitive equipment and surfaces, avoiding damage or corrosion.

Why Raised Floor Plenum Cleaning Is Critical

The raised floor plenum, designed to supply clean, pressurized air for cooling, is a common area where particles settle due to gravity. Over time, these contaminants can:

• Accumulate beneath the floor.
• Be redistributed into the equipment by airflow under pressure.
• Compromise cooling efficiency and equipment performance.

ACM’s routine plenum cleaning ensures these particles are removed, preserving the functionality and cleanliness of your air supply system.

Proven Results

ACM’s cleaning processes are designed to maintain a contamination-free environment for both your equipment and personnel:

• Cleaner Airflow: Prevents particles from recirculating into your equipment.
• Enhanced Equipment Longevity: Reduces the risk of contamination-related failures and improves overall reliability.
• Operational Efficiency: Maintains optimal cooling performance and minimizes downtime risks.

Why Choose ACM for Computer Room and Data Center Cleaning?

• Certified Expertise:

  • ACM technicians are trained to handle sensitive equipment with precision and care.

• Tailored Cleaning Solutions:

  • Every cleaning protocol is customized to your facility’s specific needs, ensuring compatibility and efficiency.

• Guaranteed Cleanliness:

  • ACM guarantees measurable improvements, leaving your computer room or data center 3 to 10 times cleaner.

Protect Your Critical Infrastructure with ACM

ACM’s proven cleaning methods ensure that your computer rooms and data centers remain contamination-free, protecting your valuable equipment and enhancing operational reliability. Contact ACM today to schedule a consultation and learn how we can help maintain the cleanliness and performance of your facility.